MEESHA follows Mithun, a forest guard, who reunites with his friends Anandhu and Imodh after two years with a secret plan in the forest. He enlists Kitho, a notorious hunter, for an illegal deer hunt. But as the night unfolds, hidden motives and strange happenings blur the line between hunter and prey, leading to an eerie climax where the real question is, who is truly being hunted?